DSIP — Wolverine Health

How it works

First isolated from rabbit cerebral venous blood during induced slow-wave sleep in the 1970s. Small human trials in the 1980s–90s showed reduced stress markers and some sleep architecture effects. The problem: the mechanism isn't clear, the blood-brain barrier penetration is disputed, and endogenous DSIP levels are difficult to measure. Decades of research have produced more questions than answers. It remains on the PCAC July 2026 docket — regulators haven't resolved what to make of it either.

FDA status: No FDA approval. Under PCAC July 23–24 2026 review for 503A bulk substance consideration.
WADA status: Permitted in sport
Route: subcutaneous injection; intranasal (experimental)

Key studies

A sleep-producing peptide from CSF of sleep-deprived rabbits — Monnier et al. (1977)

DSIP (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) was first isolated from cerebral venous blood of rabbits during induced slow-wave sleep and shown to increase NREM sleep in recipient animals.

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Research on DSIP

After the PCAC votes: what FDA reclassification actually looks like in practice

A favourable July PCAC vote is not a prescription you can fill in August. The rulemaking that follows the recommendation is where the access actually changes — and where the legitimate supply chain starts to exist.

The PCAC review is July 23–24, 2026. Here is what that means for peptide access.

Two days at FDA's White Oak campus decide which of seven peptides US compounding pharmacies will be allowed to dispense by prescription. The vote is not an approval, the docket is not all the peptides, and the framing the forums use is mostly wrong.

DSIP: Delta Sleep-Inducing Peptide Research and the PCAC July 2026 Review

Science-journalism overview of DSIP — the nonapeptide associated with sleep regulation and stress modulation, its evidence base across decades of research, and its position on the PCAC July 23–24 2026 docket.