5-Amino-1MQ — independent peptide journalism

How it works

A small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that regulates NAD+ metabolism and adipogenesis. Not a peptide by strict definition. It is a quinolinium salt. In mouse models it reduced fat mass and prevented diet-induced obesity without caloric restriction. Human data: none published. The mechanism is real; the translation is unproven.

FDA status: No FDA approval. Not on the July 2026 or February 2027 PCAC dockets.
WADA status: Not applicable
Route: oral

Key studies

NNMT inhibition mimics aspects of caloric restriction — Wilkins et al. (2021)

5-amino-1MQ, an NNMT inhibitor, reduced fat mass in diet-induced obese mice without caloric restriction by altering NAD+ metabolism and lipogenesis gene expression in adipose tissue.

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This peptide is on the PCAC review docket but hasn't been covered in depth yet. New research coverage drops regularly — join the waitlist to be first to know.