Peptide reference
A small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that regulates NAD+ metabolism and adipogenesis. Not a peptide by strict definition — it is a quinolinium salt — but listed alongside peptides on the PCAC docket. In mouse models it reduced fat mass and prevented diet-induced obesity without caloric restriction. Human data: none published. The mechanism is real; the translation is unproven.
5-amino-1MQ, an NNMT inhibitor, reduced fat mass in diet-induced obese mice without caloric restriction by altering NAD+ metabolism and lipogenesis gene expression in adipose tissue.
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Join the waitlistThis peptide is on the PCAC review docket but hasn't been covered in depth yet. New research coverage drops regularly — join the waitlist to be first to know.